Загрузка...

Exploiting temporal collateral sensitivity in tumor clonal evolution

The prevailing approach to addressing secondary drug resistance in cancer focuses on treating the resistance mechanisms at relapse. However, the dynamic nature of clonal evolution, along with potential fitness costs and cost compensations, may present exploitable vulnerabilities; a notion that we te...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Cell
Главные авторы: Zhao, Boyang, Sedlak, Joseph C., Srinivas, Raja, Creixell, Pau, Pritchard, Justin R., Tidor, Bruce, Lauffenburger, Douglas A., Hemann, Michael T.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152932/
https://ncbi.nlm.nih.gov/pubmed/26924578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.045
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!