Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer therapy today. However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensitivity to another drug. These evolutionary trade-offs can be exploited using ‘evolutionary steeri...

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Pubblicato in:Nat Commun
Autori principali: Acar, Ahmet, Nichol, Daniel, Fernandez-Mateos, Javier, Cresswell, George D., Barozzi, Iros, Hong, Sung Pil, Trahearn, Nicholas, Spiteri, Inmaculada, Stubbs, Mark, Burke, Rosemary, Stewart, Adam, Caravagna, Giulio, Werner, Benjamin, Vlachogiannis, Georgios, Maley, Carlo C., Magnani, Luca, Valeri, Nicola, Banerji, Udai, Sottoriva, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174377/
https://ncbi.nlm.nih.gov/pubmed/32317663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15596-z
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