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Addressing genetic tumor heterogeneity through computationally predictive combination therapy
Recent tumor sequencing data suggests an urgent need to develop a methodology to directly address intra-tumor heterogeneity in the design of anti-cancer treatment regimens. We use RNA interference to model heterogeneous tumors, and demonstrate successful validation of computational predictions for h...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3975231/ https://ncbi.nlm.nih.gov/pubmed/24318931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0465 |
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