Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier

Mucopolysaccharidosis type VII is a lysosomal storage disorder resulting from inherited deficiency of β-glucuronidase (GUS). Mucopolysaccharidosis type VII is characterized by glycosaminoglycan storage in most tissues, including brain. In these disorders, enzyme delivery across the blood-brain barri...

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Bibliographic Details
Main Authors: Urayama, Akihiko, Grubb, Jeffrey H., Sly, William S., Banks, William A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC515112/
https://ncbi.nlm.nih.gov/pubmed/15314220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405042101
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