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Pharmacologic manipulation of lysosomal enzyme transport across the blood–brain barrier
The adult blood–brain barrier, unlike the neonatal blood–brain barrier, does not transport lysosomal enzymes into brain, making enzyme replacement therapy ineffective in treating the central nervous system symptoms of lysosomal storage diseases. However, enzyme transport can be re-induced with alpha...
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| Publicado no: | J Cereb Blood Flow Metab |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4794098/ https://ncbi.nlm.nih.gov/pubmed/26661222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15614589 |
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