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Epinephrine enhances lysosomal enzyme delivery across the blood–brain barrier by up-regulation of the mannose 6-phosphate receptor

Delivering therapeutic levels of lysosomal enzymes across the blood–brain barrier (BBB) has been a pivotal issue in treating CNS storage diseases, including the mucopolysaccharidoses. An inherited deficiency of β-glucuronidase (GUS) causes mucopolysaccharidosis type VII that is characterized by incr...

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Detalhes bibliográficos
Main Authors: Urayama, Akihiko, Grubb, Jeffrey H., Banks, William A., Sly, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937559/
https://ncbi.nlm.nih.gov/pubmed/17646643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705611104
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