Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors

Enzyme replacement therapy (ERT) is available for several lysosomal storage diseases. Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR). Most recombinant lysosomal...

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Detalhes bibliográficos
Main Authors: Sly, William S., Vogler, Carole, Grubb, Jeffrey H., Levy, Beth, Galvin, Nancy, Tan, Yun, Nishioka, Tatsuo, Tomatsu, Shunji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1622795/
https://ncbi.nlm.nih.gov/pubmed/17015822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607053103
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