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Measurement of Ligand–Target Residence Times by (1)H Relaxation Dispersion NMR Spectroscopy

[Image: see text] A ligand-observed (1)H NMR relaxation experiment is introduced for measuring the binding kinetics of low-molecular-weight compounds to their biomolecular targets. We show that this approach, which does not require any isotope labeling, is applicable to ligand–target systems involvi...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Moschen, Thomas, Grutsch, Sarina, Juen, Michael A., Wunderlich, Christoph H., Kreutz, Christoph, Tollinger, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150660/
https://ncbi.nlm.nih.gov/pubmed/27933946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01110
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