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Measurement of Ligand–Target Residence Times by (1)H Relaxation Dispersion NMR Spectroscopy
[Image: see text] A ligand-observed (1)H NMR relaxation experiment is introduced for measuring the binding kinetics of low-molecular-weight compounds to their biomolecular targets. We show that this approach, which does not require any isotope labeling, is applicable to ligand–target systems involvi...
Gardado en:
| Publicado en: | J Med Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2016
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5150660/ https://ncbi.nlm.nih.gov/pubmed/27933946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01110 |
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