Loss of β-adrenergic–stimulated phosphorylation of Ca(V)1.2 channels on Ser1700 leads to heart failure

L-type Ca(2+) currents conducted by voltage-gated calcium channel 1.2 (Ca(V)1.2) initiate excitation–contraction coupling in the heart, and altered expression of Ca(V)1.2 causes heart failure in mice. Here we show unexpectedly that reducing β-adrenergic regulation of Ca(V)1.2 channels by mutation of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yang, Linghai, Dai, Dao-Fu, Yuan, Can, Westenbroek, Ruth E., Yu, Haijie, West, Nastassya, de la Iglesia, Horacio O., Catterall, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150375/
https://ncbi.nlm.nih.gov/pubmed/27864509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617116113
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