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Basal and β-adrenergic regulation of the cardiac calcium channel Ca(V)1.2 requires phosphorylation of serine 1700
L-type calcium (Ca(2+)) currents conducted by voltage-gated Ca(2+) channel Ca(V)1.2 initiate excitation–contraction coupling in cardiomyocytes. Upon activation of β-adrenergic receptors, phosphorylation of Ca(V)1.2 channels by cAMP-dependent protein kinase (PKA) increases channel activity, thereby a...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246329/ https://ncbi.nlm.nih.gov/pubmed/25368181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419129111 |
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