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Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response

L-type Ca(2+) currents conducted by Ca(V)1.2 channels initiate excitation–contraction coupling in the heart. Their activity is increased by β-adrenergic/cAMP signaling via phosphorylation by PKA in the fight-or-flight response, but the sites of regulation are unknown. We describe the functional role...

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Detalhes bibliográficos
Main Authors: Fu, Ying, Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845157/
https://ncbi.nlm.nih.gov/pubmed/24218620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319421110
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