טוען...
Loss of β-adrenergic–stimulated phosphorylation of Ca(V)1.2 channels on Ser1700 leads to heart failure
L-type Ca(2+) currents conducted by voltage-gated calcium channel 1.2 (Ca(V)1.2) initiate excitation–contraction coupling in the heart, and altered expression of Ca(V)1.2 causes heart failure in mice. Here we show unexpectedly that reducing β-adrenergic regulation of Ca(V)1.2 channels by mutation of...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5150375/ https://ncbi.nlm.nih.gov/pubmed/27864509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617116113 |
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