Deletion of the Distal C Terminus of Ca(V)1.2 Channels Leads to Loss of β-Adrenergic Regulation and Heart Failure in Vivo

L-type calcium currents conducted by Ca(V)1.2 channels initiate excitation-contraction coupling in cardiac and vascular smooth muscle. In the heart, the distal portion of the C terminus (DCT) is proteolytically processed in vivo and serves as a noncovalently associated autoinhibitor of Ca(V)1.2 chan...

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Detalhes bibliográficos
Main Authors: Fu, Ying, Westenbroek, Ruth E., Yu, Frank H., Clark, John P., Marshall, Misty R., Scheuer, Todd, Catterall, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069462/
https://ncbi.nlm.nih.gov/pubmed/21216955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175307
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