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Deletion of the Distal C Terminus of Ca(V)1.2 Channels Leads to Loss of β-Adrenergic Regulation and Heart Failure in Vivo
L-type calcium currents conducted by Ca(V)1.2 channels initiate excitation-contraction coupling in cardiac and vascular smooth muscle. In the heart, the distal portion of the C terminus (DCT) is proteolytically processed in vivo and serves as a noncovalently associated autoinhibitor of Ca(V)1.2 chan...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069462/ https://ncbi.nlm.nih.gov/pubmed/21216955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175307 |
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