The immunometabolite S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate

R-2-hydroxyglutarate accumulates to millimolar levels in cancers with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both R- and S-2-hydroxyglutarate, the other enantiomer of this metabolite, are detectible...

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Publicat a:Nature
Autors principals: Tyrakis, Petros A., Palazon, Asis, Macias, David, Lee, Kian. L., Phan, Anthony. T., Veliça, Pedro, You, Jia, Chia, Grace S., Sim, Jingwei, Doedens, Andrew, Abelanet, Alice, Evans, Colin E., Griffiths, John R., Poellinger, Lorenz, Goldrath, Ananda. W., Johnson, Randall S.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149074/
https://ncbi.nlm.nih.gov/pubmed/27798602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20165
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