An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was essential for the effector state in CD8(+) T cells. Furthermore, loss o...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Palazon, Asis, Tyrakis, Petros A., Macias, David, Veliça, Pedro, Rundqvist, Helene, Fitzpatrick, Susan, Vojnovic, Nikola, Phan, Anthony T., Loman, Niklas, Hedenfalk, Ingrid, Hatschek, Thomas, Lövrot, John, Foukakis, Theodoros, Goldrath, Ananda W., Bergh, Jonas, Johnson, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691891/
https://ncbi.nlm.nih.gov/pubmed/29136509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.10.003
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