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Design of a doxorubicin-peptidomimetic conjugate that targets HER2-positive cancer cells

Doxorubicin (DOX) belongs to the anthracycline class of drugs that are used in the treatment of various cancers. It has limited cystostatic effects in therapeutic doses, but higher doses can cause cardiotoxicity. In the current approach, we conjugated a peptidomimetic (Arg-aminonaphthylpropionic aci...

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Bibliografske podrobnosti
izdano v:Eur J Med Chem
Main Authors: Pallerla, Sandeep, Gauthier, Ted, Sable, Rushikesh, Jois, Seetharama D.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148673/
https://ncbi.nlm.nih.gov/pubmed/27769032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.10.015
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