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Design of novel lipidated peptidomimetic conjugates for targeting EGFR heterodimerization in HER2 + cancer
The human epidermal growth factor receptor (EGFR) family is known to be involved in cell signaling pathways. The extracellular domain of EGFR consists of four domains, of which domain II and domain IV are known to be involved in the dimerization process. Overexpression of these receptors is known to...
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| Publié dans: | Bioorg Med Chem Lett |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6283100/ https://ncbi.nlm.nih.gov/pubmed/30314880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.005 |
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