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Design of novel lipidated peptidomimetic conjugates for targeting EGFR heterodimerization in HER2 + cancer
The human epidermal growth factor receptor (EGFR) family is known to be involved in cell signaling pathways. The extracellular domain of EGFR consists of four domains, of which domain II and domain IV are known to be involved in the dimerization process. Overexpression of these receptors is known to...
Gardado en:
| Publicado en: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6283100/ https://ncbi.nlm.nih.gov/pubmed/30314880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.005 |
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