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Design of novel lipidated peptidomimetic conjugates for targeting EGFR heterodimerization in HER2 + cancer

The human epidermal growth factor receptor (EGFR) family is known to be involved in cell signaling pathways. The extracellular domain of EGFR consists of four domains, of which domain II and domain IV are known to be involved in the dimerization process. Overexpression of these receptors is known to...

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Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Main Authors: Naik, Himgauri, Gauthier, Ted, Singh, Sitanshu, Jois, Seetharama
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283100/
https://ncbi.nlm.nih.gov/pubmed/30314880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.005
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