Optimized Liquid Chromatography Nanoelectrospray-High Resolution Tandem Mass Spectrometry Method for the Analysis of 4-Hydroxy-1-(3-pyridyl)-1-butanone-Releasing DNA Adducts in Human Oral Cells

Metabolic activation of the carcinogenic tobacco-specific N-nitrosamines leads to the formation of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts. We recently developed a liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the analysis of HPB-releasing DNA adducts...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Ma, Bin, Ruszczak, Chris, Jain, Vipin, Khariwala, Samir S., Lindgren, Bruce, Hatsukami, Dorothy K., Stepanov, Irina
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148665/
https://ncbi.nlm.nih.gov/pubmed/27618873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00254
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