Quantitation by Liquid Chromatography-Nanoelectrospray Ionization-High Resolution Tandem Mass Spectrometry of DNA Adducts Derived from Methyl Glyoxal and Carboxyethylating Agents in Leukocytes of Smokers and Non-smokers

A liquid chromatograpy-nanoelectrospray Ionization-high resolution tandem mass spectrometry (LC-NSI-HRMS/MS) method was developed for quantitation of the DNA adducts 7-(2’-carboxyethyl)guanine (7–2’-CEG) and N(2)-(1’-carboxyethyl)guanine (N(2)-1’-CEG), as their methyl esters, in human leukocyte DNA...

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Publicado en:Chem Biol Interact
Main Authors: Cheng, Guang, Reisinger, Sarah A., Shields, Peter G., Hatsukami, Dorothy K., Balbo, Silvia, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682731/
https://ncbi.nlm.nih.gov/pubmed/32442416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2020.109140
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