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Analysis of 4-hydroxy-1-(-3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry

Quantitation of DNA adducts could provide critical information on the relationship between exposure to tobacco smoke and cancer risk in smokers. In this study, we developed a robust and sensitive liquid chromatography-tandem mass spectrometry method for the analysis of 4-hydroxy-1-(3-pyridyl)-1-buta...

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Autors principals: Stepanov, Irina, Muzic, John, Le, Chap T., Sebero, Erin, Villalta, Peter, Ma, Bin, Jensen, Joni, Hatsukami, Dorothy, Hecht, Stephen S.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631465/
https://ncbi.nlm.nih.gov/pubmed/23252610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300282k
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