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How do short chain non-ionic detergents destabilize GPCRs?
Stability of detergent-solubilized GPCRs is crucial for their purification in a biologically relevant state and it is well-known that short chain detergents such as octylglucoside are more denaturing than long chain detergents such as dodecylmaltoside. However, the molecular basis for this phenomeno...
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| Опубликовано в: : | J Am Chem Soc |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5148649/ https://ncbi.nlm.nih.gov/pubmed/27792324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08742 |
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