How do short chain non-ionic detergents destabilize GPCRs?

Stability of detergent-solubilized GPCRs is crucial for their purification in a biologically relevant state and it is well-known that short chain detergents such as octylglucoside are more denaturing than long chain detergents such as dodecylmaltoside. However, the molecular basis for this phenomeno...

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Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Lee, Sangbae, Mao, Allen, Bhattacharya, Supriyo, Robertson, Nathan, Grisshammer, Reinhard, Tate, Christopher G., Vaidehi, Nagarajan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148649/
https://ncbi.nlm.nih.gov/pubmed/27792324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08742
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