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How do short chain non-ionic detergents destabilize GPCRs?
Stability of detergent-solubilized GPCRs is crucial for their purification in a biologically relevant state and it is well-known that short chain detergents such as octylglucoside are more denaturing than long chain detergents such as dodecylmaltoside. However, the molecular basis for this phenomeno...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5148649/ https://ncbi.nlm.nih.gov/pubmed/27792324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08742 |
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