High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines

Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and compound-resist...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Filipuzzi, Ireos, Cotesta, Simona, Perruccio, Francesca, Knapp, Britta, Fu, Yue, Studer, Christian, Pries, Verena, Riedl, Ralph, Helliwell, Stephen B., Petrovic, Katarina T., Movva, N. Rao, Sanglard, Dominique, Tao, Jianshi, Hoepfner, Dominic
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147771/
https://ncbi.nlm.nih.gov/pubmed/27855158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006374
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