Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and yeast cells. Chemogenomic profiling in S. cerevisiae indicated that the Sec61 translocon complex, the machinery for protein translocation and membrane insertion at the endoplasmic reti...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Junne, Tina, Wong, Joanne, Studer, Christian, Aust, Thomas, Bauer, Benedikt W., Beibel, Martin, Bhullar, Bhupinder, Bruccoleri, Robert, Eichenberger, Jürg, Estoppey, David, Hartmann, Nicole, Knapp, Britta, Krastel, Philipp, Melin, Nicolas, Oakeley, Edward J., Oberer, Lukas, Riedl, Ralph, Roma, Guglielmo, Schuierer, Sven, Petersen, Frank, Tallarico, John A., Rapoport, Tom A., Spiess, Martin, Hoepfner, Dominic
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359925/
https://ncbi.nlm.nih.gov/pubmed/25616894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.165746
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