Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and yeast cells. Chemogenomic profiling in S. cerevisiae indicated that the Sec61 translocon complex, the machinery for protein translocation and membrane insertion at the endoplasmic reti...

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Published in:J Cell Sci
Main Authors: Junne, Tina, Wong, Joanne, Studer, Christian, Aust, Thomas, Bauer, Benedikt W., Beibel, Martin, Bhullar, Bhupinder, Bruccoleri, Robert, Eichenberger, Jürg, Estoppey, David, Hartmann, Nicole, Knapp, Britta, Krastel, Philipp, Melin, Nicolas, Oakeley, Edward J., Oberer, Lukas, Riedl, Ralph, Roma, Guglielmo, Schuierer, Sven, Petersen, Frank, Tallarico, John A., Rapoport, Tom A., Spiess, Martin, Hoepfner, Dominic
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359925/
https://ncbi.nlm.nih.gov/pubmed/25616894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.165746
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