High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines

Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and compound-resist...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Filipuzzi, Ireos, Cotesta, Simona, Perruccio, Francesca, Knapp, Britta, Fu, Yue, Studer, Christian, Pries, Verena, Riedl, Ralph, Helliwell, Stephen B., Petrovic, Katarina T., Movva, N. Rao, Sanglard, Dominique, Tao, Jianshi, Hoepfner, Dominic
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147771/
https://ncbi.nlm.nih.gov/pubmed/27855158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006374
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