Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents

High-throughput phenotypic screening against the yeast Saccharomyces cerevisiae revealed a series of triazolopyrimidine-sulfonamide compounds with broad-spectrum antifungal activity, no significant cytotoxicity, and low protein binding. To elucidate the target of this series, we have applied a chemo...

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Detalhes bibliográficos
Main Authors: Richie, Daryl L., Thompson, Katherine V., Studer, Christian, Prindle, Vivian C., Aust, Thomas, Riedl, Ralph, Estoppey, David, Tao, Jianshi, Sexton, Jessica A., Zabawa, Thomas, Drumm, Joseph, Cotesta, Simona, Eichenberger, Jürg, Schuierer, Sven, Hartmann, Nicole, Movva, N. Rao, Tallarico, John A., Ryder, Neil S., Hoepfner, Dominic
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632958/
https://ncbi.nlm.nih.gov/pubmed/23478965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01809-12
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