LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

Kekkon proteins negatively regulate the epidermal growth factor receptor (EGFR) during oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane protein whose inactivation in rodents promotes skin hyperplasia, suggesting involvement in EGFR regulation. We report upregu...

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Detaylı Bibliyografya
Asıl Yazarlar: Gur, Gal, Rubin, Chanan, Katz, Menachem, Amit, Ido, Citri, Ami, Nilsson, Jonas, Amariglio, Ninette, Henriksson, Roger, Rechavi, Gideon, Hedman, Håkan, Wides, Ron, Yarden, Yosef
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2004
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC514515/
https://ncbi.nlm.nih.gov/pubmed/15282549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600342
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