A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

Ligand-induced desensitization of the epidermal growth factor receptor (EGFR) is controlled by c-Cbl, a ubiquitin ligase that binds multiple signaling proteins, including the Grb2 adaptor. Consistent with a negative role for c-Cbl, here we report that defective Tyr1045 of EGFR, an inducible c-Cbl do...

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Main Authors: Waterman, Hadassa, Katz, Menachem, Rubin, Chanan, Shtiegman, Keren, Lavi, Sara, Elson, Ari, Jovin, Thomas, Yarden, Yosef
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2002
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC125825/
https://ncbi.nlm.nih.gov/pubmed/11823423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.3.303
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