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LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation
Kekkon proteins negatively regulate the epidermal growth factor receptor (EGFR) during oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane protein whose inactivation in rodents promotes skin hyperplasia, suggesting involvement in EGFR regulation. We report upregu...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2004
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514515/ https://ncbi.nlm.nih.gov/pubmed/15282549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600342 |
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