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Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

Robust biological signaling networks evolved, through gene duplications, from simple, relatively fragile cascades. Architectural features such as layered configuration, branching and modularity, as well as functional characteristics (e.g., feedback control circuits), enable fail-safe performance in...

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書目詳細資料
Main Authors: Amit, Ido, Wides, Ron, Yarden, Yosef
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2007
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174628/
https://ncbi.nlm.nih.gov/pubmed/18059446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb4100195
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