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Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

Robust biological signaling networks evolved, through gene duplications, from simple, relatively fragile cascades. Architectural features such as layered configuration, branching and modularity, as well as functional characteristics (e.g., feedback control circuits), enable fail-safe performance in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Amit, Ido, Wides, Ron, Yarden, Yosef
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174628/
https://ncbi.nlm.nih.gov/pubmed/18059446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb4100195
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