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Robustness and Evolvability of the Human Signaling Network

Biological systems are known to be both robust and evolvable to internal and external perturbations, but what causes these apparently contradictory properties? We used Boolean network modeling and attractor landscape analysis to investigate the evolvability and robustness of the human signaling netw...

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Detalhes bibliográficos
Main Authors: Kim, Junil, Vandamme, Drieke, Kim, Jeong-Rae, Munoz, Amaya Garcia, Kolch, Walter, Cho, Kwang-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117429/
https://ncbi.nlm.nih.gov/pubmed/25077791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003763
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