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Robustness and Evolvability of the Human Signaling Network

Biological systems are known to be both robust and evolvable to internal and external perturbations, but what causes these apparently contradictory properties? We used Boolean network modeling and attractor landscape analysis to investigate the evolvability and robustness of the human signaling netw...

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Autori principali: Kim, Junil, Vandamme, Drieke, Kim, Jeong-Rae, Munoz, Amaya Garcia, Kolch, Walter, Cho, Kwang-Hyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117429/
https://ncbi.nlm.nih.gov/pubmed/25077791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003763
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