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Cell signaling by receptor-tyrosine kinases

Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected diversity in the mechanisms of their activation by growth factor ligands. Strategies for inducing dimerization by ligand binding are surprisingly diverse, as are mechanisms that couple this event to activation of...

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Bibliographic Details
Main Authors: Lemmon, Mark A., Schlessinger, Joseph
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914105/
https://ncbi.nlm.nih.gov/pubmed/20602996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.011
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