LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

Kekkon proteins negatively regulate the epidermal growth factor receptor (EGFR) during oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane protein whose inactivation in rodents promotes skin hyperplasia, suggesting involvement in EGFR regulation. We report upregu...

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Main Authors: Gur, Gal, Rubin, Chanan, Katz, Menachem, Amit, Ido, Citri, Ami, Nilsson, Jonas, Amariglio, Ninette, Henriksson, Roger, Rechavi, Gideon, Hedman, Håkan, Wides, Ron, Yarden, Yosef
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC514515/
https://ncbi.nlm.nih.gov/pubmed/15282549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600342
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