TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

Aims: Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is the master transcriptional regulator of antioxidant gene expression. On increased oxidative stress, an adaptor for Nrf2 degradation, Kelch-like ECH-associated protein 1 (Keap1), is directly modulated by oxidants in the cytoplasm, wh...

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Detalles Bibliográficos
Publicado en:Antioxid Redox Signal
Main Authors: Hashimoto, Kazunori, Simmons, Alicia N., Kajino-Sakamoto, Rie, Tsuji, Yoshiaki, Ninomiya-Tsuji, Jun
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144887/
https://ncbi.nlm.nih.gov/pubmed/27245349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6663
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