TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of cell death in several cancer cells, but many cells are resistant to TRAIL. The mechanism that determines sensitivity to TRAIL-killing is still elusive. Here we report that deletion of TAK1 kinase greatly increased activation of cas...

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Hlavní autoři: Morioka, Sho, Omori, Emily, Kajino, Taisuke, Kajino-Sakamoto, Rie, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796077/
https://ncbi.nlm.nih.gov/pubmed/19421137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.110
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