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TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of cell death in several cancer cells, but many cells are resistant to TRAIL. The mechanism that determines sensitivity to TRAIL-killing is still elusive. Here we report that deletion of TAK1 kinase greatly increased activation of cas...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796077/ https://ncbi.nlm.nih.gov/pubmed/19421137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.110 |
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