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Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells

TAK1 kinase activates multiple transcription factors and regulates the level of reactive oxygen species (ROS). We have previously reported that ablation of TAK1 in keratinocytes causes hyper-sensitivity to ROS-induced cell apoptosis. It is known that some tumor cells produce ROS at higher levels com...

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Autors principals: Omori, Emily, Matsumoto, Kunihiro, Zhu, Songyun, Smart, Robert C., Ninomiya-Tsuji, Jun
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970664/
https://ncbi.nlm.nih.gov/pubmed/20959492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1227
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