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Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells
TAK1 kinase activates multiple transcription factors and regulates the level of reactive oxygen species (ROS). We have previously reported that ablation of TAK1 in keratinocytes causes hyper-sensitivity to ROS-induced cell apoptosis. It is known that some tumor cells produce ROS at higher levels com...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2970664/ https://ncbi.nlm.nih.gov/pubmed/20959492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1227 |
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