Autocatalytic self-propagation of misfolded prion protein

Prions are thought to replicate in an autocatalytic process that converts cellular prion protein (PrP(C)) to the disease-associated misfolded PrP isoform (PrP(Sc)). Our study scrutinizes this hypothesis by in vitro protein misfolding cyclic amplification (PMCA). In serial transmission PMCA experimen...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bieschke, Jan, Weber, Petra, Sarafoff, Nikolaus, Beekes, Michael, Giese, Armin, Kretzschmar, Hans
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514458/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15297610/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404650101
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