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Autocatalytic self-propagation of misfolded prion protein
Prions are thought to replicate in an autocatalytic process that converts cellular prion protein (PrP(C)) to the disease-associated misfolded PrP isoform (PrP(Sc)). Our study scrutinizes this hypothesis by in vitro protein misfolding cyclic amplification (PMCA). In serial transmission PMCA experimen...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514458/ https://ncbi.nlm.nih.gov/pubmed/15297610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404650101 |
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