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Autocatalytic self-propagation of misfolded prion protein
Prions are thought to replicate in an autocatalytic process that converts cellular prion protein (PrP(C)) to the disease-associated misfolded PrP isoform (PrP(Sc)). Our study scrutinizes this hypothesis by in vitro protein misfolding cyclic amplification (PMCA). In serial transmission PMCA experimen...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15297610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404650101 |
| Oznake: |
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