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Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein
Prion disease is characterized by the α→β structural conversion of the cellular prion protein (PrP(C)) into the misfolded and aggregated “scrapie” (PrP(Sc)) isoform. It has been speculated that methionine (Met) oxidation in PrP(C) may have a special role in this process, but has not been detailed an...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674404/ https://ncbi.nlm.nih.gov/pubmed/19416900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902688106 |
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