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Analyses of Protease Resistance and Aggregation State of Abnormal Prion Protein across the Spectrum of Human Prions
Prion diseases are characterized by tissue accumulation of a misfolded, β-sheet-enriched isoform (scrapie prion protein (PrP(Sc))) of the cellular prion protein (PrP(C)). At variance with PrP(C), PrP(Sc) shows a partial resistance to protease digestion and forms highly aggregated and detergent-insol...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784711/ https://ncbi.nlm.nih.gov/pubmed/23897825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477547 |
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