Analysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease Prions

The wide phenotypic variability of prion diseases is thought to depend on the interaction of a host genotype with prion strains that have self-perpetuating biological properties enciphered in distinct conformations of the misfolded prion protein PrP(Sc). This concept is largely based on indirect app...

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Bibliographic Details
Published in:J Virol
Main Authors: Cescatti, Maura, Saverioni, Daniela, Capellari, Sabina, Tagliavini, Fabrizio, Kitamoto, Tetsuyuki, Ironside, James, Giese, Armin, Parchi, Piero
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Prions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936149/
https://ncbi.nlm.nih.gov/pubmed/27122583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00144-16
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