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Characterization of Truncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease
In prion disease, the abnormal conformer of the cellular prion protein, PrP(Sc), deposits in fibrillar protein aggregates in brain and other organs. Limited exposure of PrP(Sc) to proteolytic digestion in vitro generates a core fragment of 19–21 kDa, named PrP27–30, which is also found in vivo. Rece...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662149/ https://ncbi.nlm.nih.gov/pubmed/18753138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801877200 |
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