Characterization of Truncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease

In prion disease, the abnormal conformer of the cellular prion protein, PrP(Sc), deposits in fibrillar protein aggregates in brain and other organs. Limited exposure of PrP(Sc) to proteolytic digestion in vitro generates a core fragment of 19–21 kDa, named PrP27–30, which is also found in vivo. Rece...

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Bibliografiske detaljer
Main Authors: Notari, Silvio, Strammiello, Rosaria, Capellari, Sabina, Giese, Armin, Cescatti, Maura, Grassi, Jacques, Ghetti, Bernardino, Langeveld, Jan P. M., Zou, Wen-Quan, Gambetti, Pierluigi, Kretzschmar, Hans A., Parchi, Piero
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662149/
https://ncbi.nlm.nih.gov/pubmed/18753138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801877200
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