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Characterization of Truncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease

In prion disease, the abnormal conformer of the cellular prion protein, PrP(Sc), deposits in fibrillar protein aggregates in brain and other organs. Limited exposure of PrP(Sc) to proteolytic digestion in vitro generates a core fragment of 19–21 kDa, named PrP27–30, which is also found in vivo. Rece...

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Bibliografske podrobnosti
Main Authors: Notari, Silvio, Strammiello, Rosaria, Capellari, Sabina, Giese, Armin, Cescatti, Maura, Grassi, Jacques, Ghetti, Bernardino, Langeveld, Jan P. M., Zou, Wen-Quan, Gambetti, Pierluigi, Kretzschmar, Hans A., Parchi, Piero
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662149/
https://ncbi.nlm.nih.gov/pubmed/18753138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801877200
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