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Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt–Jakob disease: its effect on the phenotype and prion-type characteristics

Five phenotypically distinct subtypes have been identified in sporadic Creutzfeldt–Jakob disease (sCJD), based on the methionine/valine polymorphic genotype of codon 129 of the prion protein (PrP) gene and the presence of either one of the two protease K-resistant scrapie prion protein (PrP(Sc)) typ...

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Detalhes bibliográficos
Main Authors: Cali, Ignazio, Castellani, Rudolph, Alshekhlee, Amer, Cohen, Yvonne, Blevins, Janis, Yuan, Jue, Langeveld, Jan P. M., Parchi, Piero, Safar, Jiri G., Zou, Wen-Quan, Gambetti, Pierluigi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766234/
https://ncbi.nlm.nih.gov/pubmed/19734292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awp196
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